Anthelmintic compositions



Patented Apr. 13, 948

AN THELMINTIC COMPOSITIONS John A. Whiting and David V. Whitney, J r., Kansas City, Mo., assignors to Armour and Company, Chicago, 111., a corporation of Illinois No Drawing. Application December 23, 1943, Serial No. 515,371

This invention relates to anthelmintic compositions and processes for their preparation. More particularly, it deals with such compositions which are suitable for administration to sheep and which will be readily taken by the sheep animals. Sheep animals are subject to infestation with internal parasites as are cattle and other animals, but it is. very difficult to administer anthelmintics of ordinary types to sheep. The use of a drench or capsules for forcing anthelmintics down the throat of the sheep animal is not practical, and so far as we are aware there has never been available an anthelmint-ic composition which the sheep animal will eat voluntarily. Sheep are very fastidious animals and ordinarily when an anthelmintic substance is placed in their feed they will not eat and after smelling the feed which has been so treated will actually starve themselves before they will eat of it.

We have now discovered that an anthelmintic substance may be incorporated with a material commonly known as dried brewers grain in such a way that the resulting product may be easily fed to sheep. The sheep relish this product and will eat it voluntarily, consuming any reasonable portions that are fed to them. In" this way effective amounts of anthelmintic substances may be administered to the sheep Without inconvenience and Without any need for special implements, syringes, or the like.

Our improved composition may be prepared by intimately mixing the anthelmintic substance with the dried brewers grain and, preferably, an adhesive material is mixed in to hold the anthelmintic to the surfaces of the brewers grain.

The brewers grain material is normally obtained as a result of brewing operations wherein grain such as barley, wheat, hops, etc., is digested by yeasts, the digest heated and distilled, and the grain residue dried. The dried brewers grain so obtained resembles small hulls, contains no substantial nutriment value, and is very hard to digest.

The anthelmintic substance which is mixed with the dried brewers grain may be a solution or suspension of any of the common antheL- mintics, such as nicotine, phenothiazine, etc. Preferably the anthelmintic substance should be the composition more fully described in the copending application of John A. Whiting, Serial No. 439,401 filed April 17, 1942, Patent No. 2,428,- 444 and comprising nicotine, phenothiazine, bentonite, and copper sulphate.

5 Claims. (01. 16753) materials as glue, pastes, etc.

0 Copper sulphate do The adhesive substance used in the preferred practice of the invention is a substance which will serve to bind the anthelmintlc substance to the surfaces of the dried brewers grain. The word "adhesive as referred to herein is used in its broader sense and is not limited to such A hydrocarbon oil is a good material to use as an adhesive in the practice of this invention, and other oils such as vegetable and animal oils may be used. Any non-poisonous material of sticky nature which will, due to the characteristic, serve to hold the anthelmintic to the filmy surfaces of the grain could be used.

In preparing the improved composition, the dried brewers grain may be placed in a mechanical mixer and the liquid anthelmintic substance added, the stirring being continued until there is thorough dispersion of the anthelmintic throughout the mass. Considering the nicotinephenothiazine-bentonite-copper sulphate suspension, the amount may be satisfactory in the neighborhood of 450 or 500 lbs. to each 1200 lbs. of dried brewers grain. Suitably the nicotinephenothiazine-bentonite-copper sulphate suspension may include the following ingredients in the amounts or proportions given:

Nicotine sulphate grains: 8 20 Bentonite do 20 Phenothiazine do 194 Water 11 0a-- A;

As specifically set forth in the copending application, Serial No. 439,401, the suspension may be prepared by mixing the nicotine substance, water and copper sulphate, separately mixing the phenothiazine and bentonite, and then mixing the two mixtures together.

Although thoroughly mixed with the dried brewers grain, the anthelmintic substance in itself will not adhere well and has a tendency to pass through to the bottom portion of the container when the composition is being fed. This tendency is overcome by the addition of an adhesive material such as the hydrocarbon oil. This adhesive may be added as soon as the anthelmintic substance is thoroughly mixed in, and the mixing may then be continued until the adhesive is thoroughly distributed and in contact with all parts of the mass. As to the amount of the adhesive material required, it is satisfactory to use about 20 gallons of the hydrocarbon oil to about 1200 lbs. of the dried brewers grain.

A specific example of the practice of the invention is given as follows:

193 pounds of phenothiazine are mixed with 40 pounds of bentonite, and 20 pounds of nicotine sulphate (40% aqueous solution) are mixed with water to which 20 pounds copper sulphate has been added. The two mixtures are mixed together and added to 1177 pounds of dried brewers grain. When this is thoroughly mixed, 20 gallons of hydrocarbon oil is added thereto and mixed in. The hydrocarbon oil is Sinclair No. l Paraffin Oil, having a viscosity of 150 Saybolts. The product so prepared is fed-to sheep in troughs or other suitable containers and the sheep eat it with relish.

According to a modified procedure, the phenothiazine, copper sulphate, nicotine sulphate, and bentonite are mixed together in a dry mixture and this dry mixture is added to and intimately mixed with the brewers grain. Then the water is added to the brewers grainmixture and after the water is thoroughly incorporated, the oil is then added and thoroughly mixed in.

We do not know just what it is about the brewers grain anthelmintic composition which is pleasing to the sheep animals taste but .can report the observation that the sheep will continue to eat this material whereas they refuse to eat other materials in which anthelmintic substances are incorporated.

In addition to the fact that sheep relishthe improved composition, it has the advantage of carrying the vermicide properties far into the intestinal tract. The dried brewers grains are very difficu-lt to digest, being substantially undigestible, and pass through the stomachs f the animal and well through the intestines before the anthelmintic substances are all released so that there is good contact with the various intestinal parasites. Thus, the effect of the anthelmintic is enhanced especially as to those parasites in the lower part of the alimentary tract which could not be reached by ordinary anthelmintic compositions.

The foregoing detailed description has been given for purposes of explanation only, it being understood that the invention is subject to wide variation and many changes may be made all within the spirit of the invention.

What we claim as new and desire to procure in Letters Patent is:

1. An anthelmintic composition for sheep comprising dried brewers grain and an anthelmintic substance mixed with said grain.

2. An anthelmintic composition for sheep comprising dried brewers grain, an anthelmintic substance mixed With said grain, and an adhesive for holding said anthelmintic substance to the surfacesof said grain.

3. An anthelmintic composition for sheep comprising dried brewers grain, an anthelmintic substance in admixture with said grain, and an oil coating the surfaces of said grain and binding said anthelmintic substance thereto.

4. An anthelmintic composition comprising.

REFERENCES CITED The following references are of record in the file of this patent:

UNITED STATES PATENTS Number Name Date 312,593 Wiesebrcck Feb. 1'7, 1885 353,017 Cadwell Nov. 23, 1886 855,257 Dieterichs Dec. 28,1886

1,839,970 Konantz Jan. 5, 1932 2,033,495 Taylor Mar510y1936- 2,033,856 Smith Mar. 10, 1:936 2,096,566 Smith Oct. 19, 1937 2,146,867 Welin Feb; 14,1939 2,277,680 Bosquet Mar. 31, I942 2,294,888 Austin Sept. 3,1942

OTHER. REFERENCES RobertsJournal of the Council .of Scientific and Industrial Research, Aug. 1939 (Australia),

vol. 12, page 208 (167-53).

Carlson-Veterinary Medicine, vol: 34, page 48 (1939). (Deptof Agriculture Lib.) 

